ISOLATION AND IDENTIFICATION OF 3α,17α,21-TRIHYDROXY-5α-PREGNAN-20-ONE (ALLO-TETRAHYDRO-COMPOUND S) AFTER ADMINISTRATION OF 3β, 17α,21-TRIHYDROXYPREGN-5-EN-20-ONE(17α,21-DIHYDROXYPREGNENOLONE)
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چکیده
منابع مشابه
(20S)-20-Acetamido-18-chloro-5α-pregnan-3β-yl acetate
In the title compound, C(25)H(40)ClNO(3), prepared by the thermolysis of (20S)-O,N-diacetyl-20-amino-N-chloro-3β-hydr-oxy-5α-pregnane, the three six-membered rings adopt chair conformations while the five-membered ring is in an envelope conformation. The ester group attached to ring A is in an equatorial position. All the rings are trans-fused. Intra-molecular C-H⋯O and C-H⋯Cl inter-actions occ...
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A method is provided for suppressing atherogenesis in which a cholesterol 20-hydroperoxide is administered, which is preferably one or both of the novel compounds: 20(R)-hydroperoxy-25-hydrocholesterol and 29(S)hydroperoxy-25-hydrocholesterol 20(R)-hydroperoxy-25 hydrocholesterol and 20(S)-hydroperoxy-25-hydrocholesterol are administered. The compositions 20(R)-hydroperoxy-25-hydrocholesterol a...
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The title steroid, C(23)H(35)ClO(4), is a pregnane derivative prepared by ring opening of the corresponding 5α,6α-ep-oxy steroid with BiCl(3). There are two symmetry-independent mol-ecules in the asymmetric unit that show no significant differences concerning bond lengths and angles. The conformation of the six-membered rings in both mol-ecules is close to a chair form, while the five-membered ...
متن کامل3β,12β,14α-Trihydroxypregnan-20-one
The title compound, C(21)H(34)O(4), is a steriod of the pregnane family prepared by the sequential oxidation and reduction of 3β,12β-diacet-oxy-20-ethyl-enedioxy-pregnan-14-ene. The con-formations of the six-membered rings are close to chair forms, while the five-membered ring adopts an envelope conformation. All the rings are trans-fused and an intra-molecular O-H⋯O hydrogen bond occurs. In th...
متن کامل3β-Chlorocholest-5-en-7-one
The title compound, C(27)H(43)ClO, is a steroid derivative composed of a saturated carbon fused-ring framework with an alkyl side chain. The A and C rings have chair conformations and the B and D rings assume half-chair conformations. The cholesterol side chain is fully extended with a gauche, trans conformation of the terminal methyl groups. In the crystal structure, the molecules are aligned ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1963
ISSN: 0006-2936
DOI: 10.1042/bj0880315